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Antibacterial & Antifungal

Antibacterial & Antifungal

Antibacterial & Antifungal

Moringa preparations have been cited in the scientific literature as having antibiotic, antitrypanosomal, hypotensive, antispasmodic, anti-ulcer, anti-inflammatory, hypo-cholesterolemic, and hypoglycemic activities, as well as having considerable efficacy in water purification by occlusion, sedimentation, antibiosis and even reduction of Schistosome cercariae titer.

Subsequent elegant and very thorough work, published in 1964 as a PhD thesis by Bennie Badgett (a student of the well known chemist Martin Ettlinger), identified a number of glycosylated derivatives of benzyl isothiocyanate (e.g. compounds containing the 6-carbon simple sugar, rhamnose) . The identity of these compounds was not available in the refereed scientific literature until "re-discovered" 15 years later by Kjaer and co-workers. Seminal reports on the antibiotic activity of the primary rhamnosyl ated compound then followed, from U Eilert and colleagues in Braunschweig, Germany. They reisolated and confirmed the identity of 4-(-L-rhamnopyranosyl benzyloxy) benzyl glucosinolate and its cognate isothiocyanate and verified the activity of the latter compound against a wide range of bacteria and fungi.

This is clearly the area in which the preponderance of evidence - both classical scientific and extensive anecdotal evidence - is overwhelming. The scientific evidence has now been available for over 50 years, although much of it is completely unknown to western scientists. H. pylori is an omnipresent pathogen of human beings in medically underserved areas of the world, and amongst the poorest of poor populations worldwide. It is a major cause of gastritis, and of gastric and duodenal ulcers, and it is a major risk factor for gastric cancer (having been classified as a carcinogen by the W.H.O. in 1993). Cultures of H. pylori, it turned out, were extraordinarily susceptible too, and to a number of other isothiocyanates. These compounds had antibiotic activity against H. pylori at concentrations up to 1000-fold lower than those which had been used in earlier studies against a wide range of bacteria and fungi. The extension of this nding to human H. pylori infection is now being pursued in the clinic, and the prototypical isothiocyanate has already demonstrated some efficacy in pilot studies. (Jed W. Fahey, 2005)


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